How does platelet-rich fibrin work?

Platelet-rich fibrin forms a three-dimensional network in the skin, which acts as a scaffold for new cells. Platelets, contained in the fibrin, release growth factors that stimulate collagen and elastin production, improving skin firmness and elasticity. In addition, stem cells promote repair and regeneration processes, accelerating tissue healing.

How does the platelet-rich fibrin procedure work?

Prior to the procedure, the aesthetic doctor conducts a detailed interview, which includes an assessment of the patient's health and expectations from the procedure. The doctor also assesses the condition of the skin, indications for the procedure as well as any contraindications. Based on this information, a treatment plan is established that best suits the patient's needs for the area of the body to be treated.

The procedure begins with drawing a small amount of the patient's blood - usually about 8-16 ml. The blood is drawn from a vein, usually from the elbow area. Prior to the procedure, the patient does not need to take any special preparations, unless the doctor advises otherwise, such as being fasted. The blood is used to make a preparation of platelet-rich fibrin.

After the blood is drawn, the sample is placed in a centrifuge, where the blood is subjected to high speed centrifugation, allowing the platelet-rich fibrin to be separated from other blood components like plasma and red blood cells. The process results in a preparation that contains concentrated platelets, growth factors and stem cells.

The resulting platelet-rich fibrin preparation is inserted into the skin using fine needles via mesotherapy. The process may involve several sessions, depending on the area and the patient's needs. The platelet-rich fibrin is applied to the problem area (e.g. face, neck, cleavage, hands or scalp in case of treatment of alopecia), leading to stimulation of regenerative processes. The treatment is usually fast and effective, allowing immediate improvement in skin condition.

A single procedure usually takes 45 to 60 minutes and is performed under local anesthesia. The anesthesia reduces pain and discomfort during the procedure.

Application of platelet-rich fibrin

Platelet-rich fibrin is used in:

• wrinkle and furrow reduction,
• improving skin firmness and elasticity,
• treatment of scars, including acne scars,
• reduction of dark circles and puffiness under the eyes,
• treatment of hair loss (e.g., androgenetic alopecia),
• rejuvenation of the skin of the hands and cleavage, 
• regeneration after aesthetic medicine procedures (e.g. laser therapy).

Duration of platelet-rich fibrin treatment and recovery

The procedure with platelet-rich fibrin takes between 45 and 60 minutes. After the procedure, the patient can return to daily activities, but it is recommended to avoid intense exercise and sun exposure for a few days. The effects are visible after about 2-3 weeks and last for 6-12 months, depending on the patient's individual predisposition.

What are the contraindications to platelet-rich fibrin treatment?

Treatment with platelet-rich fibrin is not recommended in cases of pregnancy and lactation, autoimmune diseases, cancer, hemorrhagic diathesis, and skin infections at the site of the planned procedure